PHYTOPHARMACOLOGICAL EVALUATION OF DALBERGIA LATIFOLIA ROXB FOR ANTIDIABETIC ACTIVITY AND ITS EFFECT ON LIPID PROFILE AND HEPATIC ENZYMES OF GLUCOSE METABOLISM IN DIABETIC RATS

Abstract

It is essential to gauge the herbal plants scientifically and proper documentation should be made to understand their medicinal properties. In current scenario there exists a very high demand for the herbal products in the entire world that led to the extensive research in many pharmaceutical industries on plant materials for the exploration of potential medicinal value. This inclination seems to be a result of people finding various alternative systems of drugs. A large number of drugs are reported to have excellent medicinal value and are in use for the treatment of diabetes. Dalbergia latifolia Roxb is evergreen, deciduous tree belongs to fabaceae family, it consist of white small flower and identified by grey bark which peels in long fibers. In the present study, qualitative and quantitative phytochemical screening of Hydroalcoholic extract of bark of Dalbergia latifolia (DLExt) and pharmacological studies involved acute oral toxicity study, oral glucose tolerance test (OGTT) hypoglycemic activity and antidiabetic activity of DLExt was done. The results suggested that Dalbergia latifolia (DLExt) induced a potent reduction in glycaemia exhibited potential to reduce the blood glucose level (BGL). The study showed that Hydroalcoholic extract of bark of Dalbergia latifolia protect massive body weight loss significantly decreased MDA in pancreas and in kidney and enhances SOD, CAT, GPx and GST activity. The involvement of DLExt reduction in level of TG, TC, LDL, VLDL and elevation in HDL level in diabetic rats was also demonstrated. The study was supported with histopathology studies and showed remarkable improvement in pancreatic tissues, normal architecture of hepatocytes and normal architecture of bowman’s capsule and renal tubules.