SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL SCHIFF’S BASES DERIVED FROM 2, 6-DICHLORO-4-TRIFLUORO METHYL ANILINE

Abstract

Schiff bases are the extremely useful class of organic compounds that are widely synthesized by condensation of primary amines with carbonyl compounds. Schiff bases are the appropriate compounds having unrivalled application in organic and inorganic chemistry. Schiff bases and their metal complexes are classified for their broad range of biological importance including antibacterial, antifungal, antiviral, anticancer, anti-HIV and antipyretic properties. Considering the numerous applications of Schiff’s bases in various fields of chemistry, there has been tremendous interest in developing efficient methods for their preparation. In the present investigation, we have designed a modish series of Schiff’s bases via reaction between various substituted aromatic vinyl aldehydes and 2,6- dichloro 4-trifluromethyl aniline in presence of acetic acid. These newly synthesized Schiff’s bases were characterized by spectral analysis and all compounds were screened for their antimicrobial activities.