SYNTHESIS AND IN VITRO STUDY OF ISOXAZOLE ANALOGUES BEARING 1, 2, 3-TRIAZOLE AS POTENT ANTIBACTERIAL AGENTS

Abstract

A new series of 3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-5-arylisoxazole 5(a-h) have been synthesized and evaluated for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Proteus vulgaris, Salmonella typhimurium, Escherichia coli. The antibacterial activity and the structure activity relationship revealed that, compounds that contain 4-methoxyphenyl (5b) and 2,6-difluorophenyl (5c) groups on isoxazole ring showed significant and equal activity against B. subtilis, S. aureus, M. luteus and P. vulgaris to that of standard drug. The other compounds also exhibited considerable antibacterial activities and therefore emerged as potential molecules.