FORMULATION DEVELOPMENT AND CHARACTERIZATION OF CLOTRIMAZOLE TRANSFERSOMAL GEL FOR EFFECTIVE TREATMENT OF FUNGAL DISEASE

Abstract

Transdermal delivery system generally shows better regulation of blood levels, decreased occurrence of systemic toxicity, no first pass hepatic metabolism, and higher compliance as compared with conventional formulations. Transdermal treatment systems are characterized as self containing and discrete dosage types, which supply the medication with a regulated rate of systemic circulation through the skin if applied to the intact skin. The aim of present work to develop transdermal drug delivery system, transfersomes incorporated gel of Clotrimazole for effective treatment of Candidiasis. Prepared formulations of Transfersomes were optimized on basis of vesicle size, shape, surface charge and entrapment efficiency. Average vesicle and zeta potential of optimized formulation F-12 was found 145.58nm and -38.25 mV respectively. Prepared gel was prepared and evaluated for viscosity, % assay, extrudability, spreadability and drug release study. It was found that viscosity of prepared gel was 3150±12 cps, % assay was 99.45±0.12, Extrudability was 175g and Spreadibility (g.cm/sec) was found that 12.32±0.42 (g.cm/sec) respectively. In vitro drug release from Transfersomes was carried out using Franz diffusion cell method and found 98.12% in 10 hr. In first 30 min., it was 182±4 drug release which is slightly high. It was due to the release of free drug present in bag after leaching from transfersomes. Drug release from transferosomal formulation was found in very sustained and controlled manner.