SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SUBSTITUTED (1H-TETRAZOL-1-YL) PYRIDINES

Abstract

Tetrazoles play a significant role in living organisms with a broad range of pharmacological activities. In the present study, a novel series of (1H-tetrazol-1-yl) pyridine derivatives were synthesized and characterized, evaluated their antiinflammatory, analgesic, ulcerogenic potential, antioxidant, and antibacterial activities. Most of the compounds showed significant in-vivo anti-inflammatory and analgesic activities. Among the synthesized compounds, 5a and 7a were found to be the most potent, showed low ulcerogenic activity in rats and found reduced and equal activity against standard drugs diclofenac sodium and nimesulide. Compounds 5a, 5c and 7b exhibited good in-vitro antioxidant activity. The antibacterial screening was done by agar diffusion method against Escherichia coli and Staphylococcus aureus. Compounds 5a, 7b and 7c were found to have good potential against S. aureus. Compound 5d possessed good activity against E. coli.