PROXIMATE ANALYSIS OF PRE-IDENTIFIED MICRO RNAs DIRECTLY RESPONSIBLE FOR TONGUE, HEAD, NECK AND ORAL SQUAMOUS CELL CARCINOMA

Abstract

Squamous cell carcinomas have very high rate of incidence since recent past. Most of these carcinomas manifest very similar features. They include head 8 neck, tongue and most importantly oral squamous cell carcinoma with thick nodules or ulcer or erosion at the sites. In India 90-95% squamous cell carcinoma includes oral squamous cell carcinoma and head 8 neck squamous cell carcinoma. In recent years, it has become clear that miRNAs are involved in normal physiological processes, including cell proliferation, differentiation, apoptosis, as well as several pathological conditions such as tumours and regulation of gene expression. It is now well established that microRNAs are a family of small non coding RNAs of 21-25 nucleotides in length and transcribed by RNA polymerase II and III, evolving precursors that undergo a series of cleavage events to form mature micro RNA. In this study, around 20 pre-identified microRNAs have been taken to analyze their role in the progression or invasiveness or apoptotic in nature for oral, head 8 neck, glottis , tongue squamous cell cancer etc. MicroRNA assembles into RNA, induces silencing complex to activate the target RNA. The expression degree in progressive groups of microRNAs and target mechanism pathways are also the matter of concern over here.