EVALUATION OF ANTICANCER PROPERTY OF BACTERIOCIN PRODUCED FROM STAPHYLOCOCCUS AUREUS

Abstract

The study was carried out to check the anticancer property of bacteriocin produced from bacteria. In this research, isolation of strain of Staphylococcus aureus was done from skin swab samples and identification of strain was done by morphological and biochemical analysis. Further, adsorption-desorption method was used for the production of bacteriocin from isolated strain and SDS-PAGE analysis revealed its proteinaceous nature. We have performed HPLC for the purification of bacteriocin. MTT and Annexin V assay depicted anticancer property of purified bacteriocin. It has been found that bacteriocin has significant antitumor activity against MDA MB 231 cell lines.