[NMP][HSO4 ]-MEDIATED ENVIRONMENTALLY BENIGN SYNTHESIS OF 4-THIAZOLIDINONE DERIVATIVES

Abstract

A N-methyl-2-pyrrolidonium hydrogensulfate [NMP][HSO₄] bronsted acidic ionic liquid-promoted cyclocondensation-cyclization pathway has been established using one pot reaction of anilines, aldehydes and mercaptoacetic acid to give 4-thiazolidinone derivatives in good to promising yields using microwave irradiation. Applications for this protocol are easy workup, high yields, short reaction times, variability of functional groups, recyclability and solvent-free conditions.