FORMULATION AND CHARACTERIZATION OF ACECLOFENAC LOADED STARCH MICROSPHERE

Abstract

Microspheres are a new category of novel drug delivery system which targets to increase the bioavailability and is formulated expediently to obtain prolonged or controlled drug delivery system in the body. Aceclofenac; a non steroidal anti inflammatory drug, is used to treat hurting rheumatic conditions such as osteoarthritis, rheumatoid arthritis and alkylosing spondylitis. It eases pain and reduces inflammation at various sites. Aceclofenac acts by blocking the effect of chemical mediators called cyclo-oxygenase (COX) enzymes which are released at inflamed regions. The aim of this research was to formulate Aceclofenac loaded starch microspheres and evaluate its in vitro properties to enhance the bioavailability of aceclofenac tablet. Aceclofenac loaded starch microspheres were prepared using emulsion cross linking method. Aceclofenac microspheres loaded with starch polymer were characterized, evaluated and it was found to influence all the parameters. The microspheres prepared showed great entrapment efficiency. In vitro release of all prepared polymeric formulations was quite good.