EFFECT OF ISOFLAVONES AS ANTIBACTERIAL AND ANTI-QUORUM SENSING AGENTS AGAINST CHROMOBACTERIUM VIOLACEUM

Abstract

Multidrug resistance is one of the emerging challenges confronted by the human race by pathogenic microorganisms causing dreadful diseases. Usage of antibiotics inappropriately has caused resistance which could lead to extreme consequences on the lives of humans. Quorum sensing (QS) is communication between cells based on the bacterial population and density. QS plays a vital role in bacterial virulence and emerging bacterial resistance. Chromobacterium violaceum aids in detecting QS modulation which is measured by violacein pigment quantification. Genistein and daidzein are isoflavones-phytoestrogen found to be beneficial in managing post menopause systems and also antioxidant-rich. The present study was conducted to understand whether these phytoestrogens genistein and daidzein interfere to inhibit biofilm formation and quorum sensing by preventing cross talk between bacteria. AntimicrobialChromobacterium violaceum. Results indicated the cytotoxic effect of genistein wherein daidzein and genistein were found to have anti-quorum sensing and biofilm inhibition. This could be of therapeutic influence against antibiotic resistance in future.