POTENTIALLY ACTIVE METAL OF COBALT, COPPER AND ZINC COMPLEXES DERIVED FROM SCHIFF BASE LIGAND OF 3-ETHOXY-2-HYDROXY-BENZALDEHYDE AND ANILINE FOR THEIR ANTICANCER ACTIVITY

Abstract

New Schiff base transition metal complexes derived from 3-ethoxy-2-hydroxy-benzaldehyde and aniline were characterized by magnetic susceptibility measurements, molar conductance, MS, FT-IR, ¹H-NMR, ¹³C-NMR, Absorbance and EPR spectra. The spectral evidences clearly showed that all the metal chelates distorted octahedral geometry except Zn(II) complex which exist square planar geometry. Electron Spin Resonance (ESR) spectrum of [CuL] complex was coinciding with proposed geometries and other reported complexes. All the synthesized compounds were studied for anticancer studies by MTT method using Hela cells. From anticancer activities, the observed IC₅₀ values of synthesized complexes are significantly higher than standard Cis-platin. The cytotoxicity of the tested compounds against the Hela cell line pursued their order Co(II) > Cu(II) > Zn(II) > ligand. Among them, Co(II) complex showed higher cytotoxic activity than other complexes and Schiff base.