PHARMACEUTICAL ASPECTS OF MICELLAR SOLUBILIZATION OF SALICYLIC ACIDS USING DIFFERENT SURFACTANTS

Abstract

Fluorescence spectroscopy is a critical tool for exploring interaction between micelles and the molecules. In recent years, extensive researches have been made on the effects of the micelles formed by the different types of surfactants, on diverse systems. Micellar solubilization is widely useful in pharmaceutical industry due to formulation of sparingly soluble drugs in soluble form. This research paper aims to provide unusal approach for the analytical and medical applications of Salicylic acid based on its solubilization in micellar media. Micellar solubilization of Salicylic acids in nonionic, anionic and cationic surfactants is monitored by fluorescence techniques. Absorption spectra was taken by UV-VIS spectrophotometer. The calculated empirical fluorescence coefficient (kf ) values are in good agreement with the fluorescence intensity. In conclusion the process of solubilization of salicylic acid in micellar medium facilitates the easy drug delivery to the patients.