A NETWORK PHARMACOLOGY-BASED APPROACH OF TRADITIONAL INDIAN MEDICINAL PLANT SOLANUM NIGRUM LINN AGAINST HEPATOCELLULAR CARCINOMA

Abstract

Solanum nigrum (SN) has been widely used in traditional folk medicine to cancer treatments, but the defined target is not
clear. To identify the potent targets for the treatment of HCC using various strategies, 23 active compounds were
collected by IMPPAT and TCMSP databases based on their DL and ADME properties. PharmMapper, SEA, STITCH and
DRAR-CPI followed to CTD and PHARMGKB were used for target fishing. 25 targets were retrieved to analyze
GeneMANIA and DAVID. Cytoscape 3.6.1 was used for the network’s constructions compound-target, target-pathway,
compound-target-pathway and target organ networks were developed. For target validation, molecular docking GLIDE,
AutoDock Vina and iGEMDOCK were used. Majorly, 21 targets were located in the liver, are considered as primary
targets for in silico docking. The study concludes 5 potent targets and 4 active compounds via 4 signaling pathways
involving HCC metabolism. SN could be potentially beneficial in treating HCC.