DEVELOPMENT AND STANDARDIZATION OF POLYHERBAL FORMULATION

Abstract

The most important challenges posed by herbal formulations is their evaluation and standardization. Evaluation is necessary to ensure the quality and purity of the herbalproduct. For evaluation of raw materials and poly herbal formulation various parameters are studied as per the World Health Organization's guidelines and the Ayurvedic Pharmacopoeia of India. The present study deals with formulation the polyherbal formulation prepared from hydro-alcoholic (30:70) extracts of Andrographis paniculata(Stem and leaves), Asparagus racemosus(Root) , Ipomoea digitata (Rhizome), Tinospora cordifolia(Stem) and Withania somnifera(Root). To evaluate of raw materials include physicochemical studies like ash values, extractive values, phytochemical studies and safety profiles which include heavy metal analysis, pesticide residue analysis and microbial load analysis. The Preformulation parameters and parameters for finished product (hard gelatin capsule) include uniformity of weight, disintegration time, moisture content, pH, phytochemical estimation and microbial load assay. The HPTLC finger print profile of finished product was also carried out.