STANDARDIZATION AND ANTI-INFLAMMATORY POTENTIAL OF AMOORA ROHITUKA AND MELIA AZEDARACH BELONGS TO FAMILY MELIACEAE

Abstract

The Meliaceae plants are known to be rich sources of limonoids. A number of limonoids have been isolated from several genera of Meliaceae and some of them exhibit anticancer, antimalarial, cytotoxic, antiprotozoal, antifeedant and many various activities. Anti-inflammatory effect of the alcoholic, hydroalcohalic (40:60) and aqueous extracts of the Amoora rohituka and Melia azedarach stem barks were studied in albino rat using the carageenan induced rat paw oedema method. The hydro alcoholic extracts of both the stem barks found to inhibit the carageenan induced rat paw oedema at dose of 100 mg/kg p.o., where the standard drug was Indomethacin at dose 10 mg/kg p.o. The results indicated that the hydro alcoholic extracts of Amoora rohituka and Melia azedarach stem barks produced significant (p less than 0.05) antiinflammatory effect when compared with Indomethacin as standard at dose 10 mg/kg p.o.