ANTIBACTERIAL AND ANTIFUNGAL SCREENING OF AMOORA ROHITUKA, MELIA AZEDARACH AND SOYMIDA FEBRIFUGA STEM BARKS

Abstract

Human kind has been subject to infections by micro-organisms since before the dawn of recorded history. One presumed that mankind has been searching for suitable therapy for all infections. The Amoora rohituka, Melia azedarach and Soymida febrifuga belongs to same family i.e. Meliaceae. The Meliaceae plants are known to be rich sources of limonoids. A number of limonoids have been isolated from several genera of Meliaceae and some of this exhibit anticancer, antimalarial, cytotoxic, antiprotozoal, antifeedant and many various activities. The stem barks of Amoora rohituka, Melia azedarach and Soymida febrifuga exist these common therapeutic activities. The antibacterial and antifungal screening of alcoholic, hydroalcohalic (40:60) and aqueous extracts of Amoora rohituka, Melia azedarach and Soymida febrifuga stem barks were studied against gram’s positive bacteria, gram’s negative bacteria and fungal strains using Agar cup method. Alcoholic, hydroalcohalic (40:60) and aqueous extracts of Amoora rohituka, Melia azedarach and Soymida febrifuga stem barks extracts were used at dose of 500 mcg/cup, where the standard antibacterial drug was Kanamycin at dose of 500 mcg/cup and 30 mcg/cup and standard antibacterial drug was Ketoconazole at dose of 100 mcg/cup and 30 mcg/cup. The results indicated that the hydroalcoholic extracts of Amoora rohituka, Melia azedarach and Soymida febrifuga stem barks have significant antibacterial and antifungal activities when compared to standards.