SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL THIAZOLIDINONE DERIVATIVES

Abstract

Thiazolidine is a five membered ring with one nitrogen and one sulphur atoms. Hydrazides and their hetrocyclized derivatives also found to passes an important role in biological activities. Thiazolidinone derivatives showed good pharmacological properties. On the basis of literature study the objective of the present work was to prepare new derivatives of hydrazide containing thiazolidine moiety. In the present work we have prepared 12 novel thiazolidinone derivatives. The newly synthesized compounds were analyzed by IR, 1H-NMR and Mass spectral analysis. The entire series of synthesized compounds was evaluated for their biological activities.