SYNTHESIS CHARECTERIZATION AND BIOLOGICAL EVALUATION OF A SERIES OF 4-CHLORO–N-(3-CHLORO-2-(ARYL)-4-OXOAZETIDIN-1-YL) BENZAMIDE DERIVATIVES

Abstract

Azetidinone is a four member heterocyclic moiety with one nitrogen atom and one carbonyl group.It is a also known as a β-lactam. It is named β-lactam because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl group.It shows a wide spectrum of biological activities against gram positive and gram negative bacteria. Besides its antibacterial property azetidinones are found to exhibit anti-tubercular, anti-convulsant, anti-cancer, anti-inflammatory, anti-microbial, etc. activities. In the present work we have synthesized a series of 12 azetidinones derivatives. Structures of newly synthesized azetidinone derivatives were confirmed by analytical techniques like IR, 1H-NMR and Mass spectrometry methods. Broth dilution method was used to determine anti-bacterial and anti-fungal activities of the synthesized compounds.