STRUCTURAL CHARACTERIZATION, ANTIMICROBIAL, ANTIOXIDANT, MOLECULAR DOCKING STUDIES OF NOVEL 4-(2,4-DIMETHOXYPHENYL)-2,6-BIS(1,3-THIAZOL-2-YL)PYRIDINE AND ITS CU(II) 8NI(II) COMPLEXES

Abstract

In the present study, we reported a novel ligand 4-(2,4-dimethoxyphenyl)-2,6-bis(1,3-thiazol-2-yl)pyridine and its Cu(II) and Ni(II) complexes were prepared. All the synthesized compounds have been characterized by 1H NMR, 13C NMR, Mass, UV, FT-IR, and ESR spectra. Synthesized ligand and its Cu(II) and Ni(II) metal complexes were screened for their antimicrobial and the compounds showed mild activity in comparison with a standard. Also, all the synthesized compounds were studied for their antioxidant activity and hemolytic activity. The antioxidant activity of the ligand (SM- 2b) and its metal complexes were evaluated by the reduction of 1,1-diphenyl-2-picryl hydrazyl (DPPH) and compounds found to be potent antioxidants. Interestingly, ligand and its complexes exhibit non-toxic property as it did not cause any effect to human erythrocyte, suggesting its nontoxic nature.