SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITIES OF NOVEL TRIDENTATE LIGAND AND ITS CU(II) 8 NI(II) COMPLEXES

Abstract

In the present study, we reported a novel (NNN) type ligand 2,6-bis(1,3-thiazol-2-yl)-4-(2,4,5- trimethoxyphenyl)pyridine and its Cu(II) and Ni(II) complexes. The synthesized were characterized by FT-IR, 1H NMR, 13C NMR, Mass, UV and ESR spectra. The antioxidant activity of the synthesized compounds were evaluated by the percentage of inhibition of 1,1-diphenyl-2-picryl hydrazyl (DPPH) and compounds found to be potent antioxidants. The synthesized compounds screened for their antimicrobial activity and results showed that the synthesized compounds showed mild antimicrobial activity in comparison with standard drugs. Copper complexes showed good antimicrobial activity than ligand as well as Nickel complex. Fascinately, ligand and its complexes exhibit non-toxic property as they did not cause any effect to human erythrocyte, which shows its nontoxic nature.