Anti-oxidant Activity of 2-hydroxyacetophenone Chalcone

Abstract

The novel series of chalcone was synthesized by 2-hydroxyacetophenone and substituted aldehyde. The structure of the synthesized compound was elucidated by melting point, retention factor, I.R. spectroscopic technique, 1H NMR and elemental analysis. A series of various substituted chalcone were evaluated for in- vitro anti-oxidant activity by 2, 2-diphenyl-1-picrylhydrazyl method. Among the entire synthesized compound IIf showed the most potent anti-oxidant activity and the other derivatives like IId, IIe, IIg, IIk and IIm was showed mild anti-oxidant activity.