A SHORT REVIEW ON THE RECENT ADVANCEMENT OF FLUORESCENT PROBES FOR FORMALDEHYDE SENSING 2017 ONWARD

Abstract

Formaldehyde is not only a ubiquitous chemical pollutant in indoor environments but also a reactive carbonyl species in biological processes. Formaldehyde is endogenously produced through the essential biological processes, including mitochondrial one-carbon metabolism, metabolite oxidation, and nuclear epigenetic modifications. High electrophilic property allows it high reactivity with a wide variety of biological nucleophiles, which can be beneficial or detrimental to cellular function depending on the situation. Therefore, it is important to develop non-invasive sensing technique for monitoring the roles and functions of FA in biological processes. So, development of a rapid, sensitive and facile method to determine the concentration of FA becomes highly desirable. Fluorescence detection technique is highly attractive because of its high selectivity, sensitivity and real-time approach. This review article focuses on various design strategies of the fluorescent probes, their sensing mechanism for detecting formaldehyde in environment as well as in living cells based on different recognition groups from 2017 onward. This area still in prime focus because of the rapid development of the fluorescence probes from lab to indoor in near future.