INFLUENCE OF pH, SURFACTANTS, AND SINK CONDITION ON DISSOLUTION RATE OF BCS CLASS II DRUGS SERTRALINE HCL AND INDOMETHACIN

Abstract

Surfactants are commonly used in molecular biology, as well as in the formulation of new and advanced pharmaceutical preparations. Surfactants execute cellular membrane features, emulsification, solubilization, and transport of substances that are otherwise insoluble in living tissues to some extent. In the present study, the influence of pH, surfactant, and sink condition on the Dissolution Rate of BCS class II drugs was studied. BCS class II drugs like Indomethacin and Sertraline HCl can be used to study the effect of pH, sink condition, and surfactants on dissolution rate. The rationale behind this study is that the drug should be dissolved appropriately within the gastrointestinal tract (GIT) to get absorbed into the body system. On the other hand, dissolution has become the most significant parameter to determine drug release behaviour and also to determine product quality. The results showed that by the addition of surfactants, dissolution rate was increased to a greater extent. The comparative study was done at different pH and also at different surfactant concentrations.