A COMPARATIVE STUDY OF EFFECT OF HYDROPHILIC POLYMERS ON DISSOLUTION RATE OF ACECLOFENAC

Abstract

Biopharmaceutics Classification System (BCS) takes into account solubility and intestinal permeability. The BCS has proven to be a very helpful and widely accepted starting point for pharmacological product development and regulation in the pharmaceutical industry. Aceclofenac is a nonsteroidal anti-inflammatory medication (NSAID) that is used to treat inflammation. Osteoarthritis, rheumatoid arthritis, dysmenorrhoea, acute lumbago, musculoskeletal trauma, and gonalgia are among the conditions for which it is commonly recommended. To manufacture prolonged release matrix tablets, hydrophilic polymers are often employed. The persistent action of these polymers was demonstrated by the formation of a thick gel layer around the matrix. This gel layer is critical in regulating the medication's release in the tablet's body. The purpose of this research is to formulate, optimise, and evaluate the effect of various hydrophilic polymers such as hydroxypropyl methyl cellulose (HPMC), hydroxyethyl cellulose (HEC), polyvinyl pyrrolidone (PVP) of various viscosities such as PVP K25, PVP K30, PVP K90, and polyethylene glycol (PEG-4000) on the dissolution rate of aceclofenac in various ratios of 1:4, 1:8 and 1:12. To manufacture prolonged release matrix tablets, hydrophilic polymers are often employed. The persistent action of these polymers was demonstrated by the formation of a thick gel layer around the matrix. This gel layer is critical in regulating the medication's release in the tablet's body.