FORMULATION DEVELOPMENT AND EVALUATION OF IVERMECTIN LOADED EMULGEL

Abstract

Emulgel is the topical drug dosage form in which emulsions are gelled by mixing with gelling agents. Incorporation of emulsion into gel increases the stability of emulsion and provides the controlled release system. Emulgel is the promising drug delivery system for delivering of hydrophobic drugs. Emulgel has several favorable properties for dematological use such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non-staining, long shelf life, and pleasant appearance. They have the dual drug releasing system i.e., gel and emulsion. The purpose of the present study was to develop and optimize the emulgel system for Ivermectin using Carbopol 941 gelling agent. The prepared emulgels were evaluated in terms of appearance, pH, spreadability, viscosity, drug content and in-vitro drug release. In-vitro diffusion studies were carried out using pH 7.4 phosphate buffer and formulation F3 (Carbopol 941-1%) has shown best results with zero order release kinetics and diffusion mechanism.