FORMULATION AND EVALUATION OF VANCOMYCIN LOADED NIOSOMAL GEL

Abstract

The present study was aimed to investigate the delivery potential of vancomycin containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of Soya PC: Span 80 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Average vesicle size of optimized formulation F9 was 158.85 nm. The Zeta potential was found 38.25%. Entrapment efficiency of optimized Niosome formulation (F9) was found as 78.85%. Further, niosomes were incorporated into gel base and characterized for viscosity, % entrapment, extrudability, spreadability and drug release study. It was found that viscosity of prepared gel was 3310±25 cps, % assay was 98.95±0.2 %, extrudability was 175±4 g and spreadibility (g/cm/sec) was found that 8.56±0.25 (g/cm/sec) respectively. In vitro drug release from niosome gel was carried out using franz diffusion cell method. The percentage drug release of optimized formulation was found to be 96.65±0.14 after 12 hrs.