SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVELTHIAZOL DERIVATIVES OF N-((2-CHLOROPHENYL)DIPHENYLMETHYL)-4-PHENYLTHIAZOL-2-AMINE

Abstract

In present work we synthesized novel series of thiazole derivatives of N-((2-chlorophenyl)diphenylmethyl)-4- phenylthiazol-2-amine in the presence of dichloromethane and triethylamine in good yield. The different studies indicate that newly synthesized compounds possess moderate to good biological activities. The title compounds have been synthesized with several structural variations. Biological evaluation of all the synthesized compounds has been carried out in vitro for their antibacterial and antifungal efficacy against various bacterial and fungal strains. The structure of synthesized compounds were characterized by their spectral (IR, 1H NMR and Mass) data.