SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF A SERIES OF (SUBSTITUTED (4-CHLOROPHENYL)-N'-((2-CHLOROQUINOLINE-3-YL) METHELENE)-5-METHYL- 1H-1,2,3-TRIAZOLE-4-CARBOHYDRAZIDE) DERIVATIVES

Abstract

A series of substituted1-(4-chlorophenyl)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide derivatives have been synthesized and assessed for their in vitro antimicrobial activity against three gram negative and two gram positive strains of bacteria and one fungal strain. Salt formation of 4-chloro aniline with sodium azide was taken place to form triazole moiety and was reacted to hydrazine hydrate to yield carbohydrazide. This carbohyrdazide was then condensed with various substituted quinolines to obtain various derivatives. In the present work we have synthesized some potent derivatives and characterizations of all novel compounds were conducted by IR, Mass, 1HNMR and 13C NMR spectral data. Broth dilution method was used to determine anti-bacterial and anti-fungal activities of synthesized organic compounds.